19608-29-8 Anti Hair Loss Powder 99% Purity Way 316606 Hair Loss

Factory Anti-Hair Loss Treatment Product Way 316606 Treat Hair Loss
 
WAY-316606 is a potential new treatment for hair loss. It is an inhibitor of the protein sFRP-1. sFRP-1 acts as a modulator of Wnt pathways. The Wnt pathways play a large role in the transcriptions of genes which then leads to how the genes are expressed. Cell differentiation typically occurs in the dermal papillae (DP) near the base of the hair follicle. During this period of growth, proteins such as sFRP-1 are produced throughout the protein. Overexpression of sFRP-1 during this phase can lead to structural defects in the hair strand.
Since the Wnt pathway plays an important role in cell determination, researchers have begun to examine what long lasting effects exist when the Wnt pathway is blocked by sFRP-1. One of the primary concerns is that with the Wnt pathway inhibited, it will not be able to modulate the activity of the protein -catenin, specifically in the hair follicle bulbs. In order to determine the magnitude of the inhibitory effects Wnt signaling has on -catenin, researchers Hawkshaw et. Al treated a hair follicle for 48 hours with an inhibitor of Wnt production-2 (IWP-2). By treating the follicle with IWP-2, there was a drastic decrease in the transcription of axis inhibition protein 2 (AXIN2) and lymphoid enhancer binding factor 1 (LEF1), both of which promote the canonical activation of -catenin. This indicates that Wnt pathway signaling is an important factor of -catenin activation in the hair follicle.
 

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